Aromatherapy confirms banana-apricot fragrance dilates the bronchi

Smelling receptors discovered in the bronchi

In the muscle cells of the human bronchi, researchers have discovered two types of olfactory receptors. If the appropriate fragrances activate these receptors, the bronchi expand or constrict - a potential approach to asthma therapy. This was the result of a team led by Prof. dr. Dr. Dr. habil Hanns Hatt and dr. Benjamin Kalbe from the Bochum Department of Cell Physiology.

Banana apricot fragrance dilates bronchi
The newly discovered on the muscle cells receptors are called OR2AG1 and OR1D2. The researchers also identified the perfumes that match the olfactory receptors and the signaling pathways that trigger them in the cell.

Amyl butyrate, a fruity fragrance with banana and apricot notes, activates the receptor OR2AG1. Binds the perfume, relaxes and dilates the bronchi. The effect was so strong in the experiment that it could nullify the effect of histamine. The body releases this substance in allergic asthma, which causes the bronchi to constrict.

Approach to asthma therapy
"Amyl butyrate could help improve asthma in asthma," concludes Hanns Hatt. "Presumably, it can not only counteract the effects of histamine, but also those of other allergens that interfere with breathing." Also for the treatment of other diseases, such as chronic obstructive pulmonary disease, the receptor may be interesting.

The researchers also showed that amyl butyrate initiates the same signaling pathways in the muscle cells as it does in the nose's olfactory cells.

Second receptor with opposite effect
The second receptor OR1D2 is susceptible to scents with floral, oily notes, such as Lilial or Bourgeonal. If the fragrance binds to the receptor, the opposite happens as with the receptor OR2AG1: The bronchial muscles contract. In addition, inflammatory substances are released in the cells. The study can be found here. (Pm)