Random finding drug prevents weight gain with high-fat food intake

Eating without increasing, something is possible?

Especially in this day and age most people try to lose weight and avoid overweight. Of course, there are quite a few diets and forms of dietary change that promise to lose weight. Are there any other ways to maintain a healthy body weight? Researchers now found that a given drug could allow you to eat more without gaining weight.

Researchers at the internationally acclaimed Yale University found in their current research that a particular drug could prevent weight gain despite the high food intake. The physicians published the results of their study in the English-language journal "Science".

A wrong diet leads to overweight and obesity. Will it be possible in the future for people to take a drug and then eat what they want without gaining weight? (Image: Creativa Images / fotolia.com)

Despite high-fat diet, the mice remained slim

Actually, the experts wanted to create a morbidly obese mouse, but they created a mouse, which indeed consumed a lot of food, but did not get fat. The scientists had removed two genes in the lymphatic tissue for their study, in order to influence the absorption of fat particles (chylomicrons). The researchers expected that this procedure would make the mice fat. But despite a high-fat diet, the mice actually stayed lean.

What are lipids?

The mice lacking the two genes excreted so-called lipids and gained little weight despite a high-fat diet. Lipids are taken up in the intestinal lymphatic tissue by entry into vessels called Lacteae. Mostly the passage of lipids to the vessels is controlled by button-shaped structures.

The modified mice did not increase

Instead of converting fat in the diet into body fat, the genetically modified mice displaced the lipids and did not increase. Therefore, of course, the question was whether this is also possible in humans. The findings of the current investigation could pave the way for a new drug, which could contribute to the fight against obesity, so the researchers hope.

How can the same effect in humans be triggered??

Instead of changing people's genes, the experts also looked for ways to trigger the same effect without interfering with the genes. They came across an inhibitor that can also affect the absorption of lipids.

Glaucoma medication could have a similar effect

It turned out that a drug already exists for this purpose, but is currently being used to treat the eye disease glaucoma, the researchers report. They found that the medication can also block the pores of the lymphatic vessels in the gut and inhibit fat absorption. Such a drug could in future be tested in humans for lipid-lowering effects. However, it will be some time before these drugs become available as a weight loss technique in humans.

Obesity can make you sick

It is important to fight obesity and obesity. More and more people are suffering from too much weight and the consequences. For example, obesity may increase the risk of various diseases, including heart attack, stroke, type 2 diabetes, and eleven different types of cancer. (As)