Science finds new genes for a longer life

Physicians are studying the effects of certain genes on life expectancy

Most people certainly hope to reach old age as healthy as possible. Researchers have now discovered new genes that are related to the life expectancy of parents. Maybe one day these genes can be used to extend the life expectancy of humans.

Researchers at the University of Exeter Medical School found in their study that previously undiscovered genes affect the life expectancy of parents. This has increased the number of genes known to positively affect life expectancy. The experts published a press release on the results of their study.

Researchers found in a study various previously unknown genes, which seem to have an effect on life expectancy. These could be used in the future to give people a longer life expectancy. (Image: pikselstock / fotolia.com)

Scientists analyze the data of 389,166 subjects

How long we live depends on a number of factors, including our lifestyle and balanced levels of blood pressure and cholesterol. But genetics and how long our parents have lived play an important role in their lifespan. The study performed a genome-wide search for variants that affect how long the parents of the participants lived. The research team examined a total of 389,166 volunteer participants. Volunteers' DNA samples carry the genetics of their biological parents, allowing experts to identify and investigate exceptionally long lifetimes.

Other genetic variants affecting life expectancy were found

Eight genetic variants have been associated with human life span, mainly heart disease and dementia. The new study allowed these genetic variants to be expanded to a total of 25 genes. Some of these genes were specific to the lifespan of mothers or fathers.

Manipulation of inflammatory and cardiovascular signaling pathways can prolong lifespan

"We have identified new ways to survive and confirm other existing pathways. Inflammatory and cardiovascular pathways offer potentially modifiable targets to reduce the risk of death and improve health, "explains Dr. Luke Pilling in the press release.

Genes involved in senescence play an important role

Genes involved in so-called senescence (a condition cells take after injury) play an important role in longevity, the researchers say. It has been proven that senescence-targeted drugs prolong the life of laboratory animals. Inflammatory and autoimmunity-related genes could in the future enable anti-inflammatory treatments that could prolong life, researchers suggest.

Blood pressure and cholesterol levels should be monitored throughout life

The study also found evidence that the average life span genetic variants also affected an exceptionally long life expectancy. "This study helps pave the way for a new treatment. The strong role of genes that affect the risk of heart disease underscores the importance of controlling blood pressure and cholesterol levels throughout life, "explains study leader Professor David Melzer of the University of Exeter Medical School.

Healthy lifestyle can reverse the negative effects of many genes

A healthy lifestyle is very important and can probably compensate for the negative effects of most genes found so far, the experts speculate. The results expand the number of genetic markers that are now associated with exceptional longevity, say the experts. More importantly, the findings add to a growing body of knowledge that highlights specific goals and biological pathways that help develop interventions that preserve health and independence later in life, the researchers add. (As)