Multiple sclerosis plant peptide can help

Researchers demonstrated in the mouse model that a special synthetic plant peptide (cyclotide) can inhibit the development of common clinical signs of multiple sclerosis (MS). Even a single oral dose of the drug has greatly improved the symptoms.

Picture: ag visual - fotolia

The discovery of the Viennese scientists gives hope that they stop the MS disease already at a very early stage or at least slow down their development.

In an animal model of MS, the onset of symptoms has been significantly reduced by the oral administration of cyclotides. So it could be that the time between spurts is prolonged or possibly an outbreak of the disease can be prevented.

Cyclotides are macrocyclic plant peptides that can be isolated from all major plant families (e.g., coffee plants, cucurbits, but also grasses and nightshade family) and therefore represent a versatile and large group of natural products. Cyclotides suppress the messenger interleukin-2 and thus the cell division of the T cells, which act as "killer" or "helper" cells in the reaction of the human immune system.

Cyclotides may therefore also be used in other diseases characterized by an overactive, misdirected immune system, such as rheumatoid arthritis. The resulting drug can be taken orally. (Pm)